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JTE-952

Chemical Structure : JTE-952

CAS No.: 1255303-54-8

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JTE-952 (PF-07265804, ARRY382, PF07265804)

Catalog No.: PC-36143Not For Human Use, Lab Use Only.

JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM.
    JTE-952 is also effective against a mouse collagen-induced model of arthritis (mouse CIA-model).

    Physicochemical Properties

    M.Wt 518.61
    Formula C30H34N2O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-(3-(4-((4-cyclopropylbenzyl)oxy)-3-methoxyphenyl)azetidin-1-yl)(4-((2,3-dihydroxypropoxy)methyl)pyridin-2-yl)methanone

    References

    1. Ikegashira K, et al. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.

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