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Chemical Structure : JTE-952
CAS No.: 1255303-54-8
Catalog No.: PC-36143Not For Human Use, Lab Use Only.
JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $728 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM.
JTE-952 is also effective against a mouse collagen-induced model of arthritis (mouse CIA-model).
| M.Wt | 518.61 | |
| Formula | C30H34N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-(3-(4-((4-cyclopropylbenzyl)oxy)-3-methoxyphenyl)azetidin-1-yl)(4-((2,3-dihydroxypropoxy)methyl)pyridin-2-yl)methanone |
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1. Ikegashira K, et al. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.
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