JVW-1034 | Probechem Biochemicals

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Chemical Structure : JVW-1034

JVW-1034 (JVW1034)

Catalog No.: PC-63494Not For Human Use, Lab Use Only.

JVW-1034 is a selective small molecule modulator of σ2R/Tmem97 with Ki of 23 nM, 10-fold weaker affinity for σ1R (Ki=248 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JVW-1034 is a selective small molecule modulator of σ2R/Tmem97 with Ki of 23 nM, 10-fold weaker affinity for σ1R (Ki=248 nM).
JVW-1034 reduces alcohol withdrawal behavior via an ortholog of σ2R/TMEM97.
JVW-1034 significantly reduces excessive alcohol drinking selectively in alcohol-dependent rats, without affecting alcohol drinking in non-dependent rats.

Physicochemical Properties

M.Wt	311.853
Formula	C20H22ClN
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-chloro-2-phenethyl-1,2,3,4,5,6-hexahydro-1,6-methanobenzo[c]azocine

References

1. Scott LL, et al. Neuropsychopharmacology. 2018 Apr 20. doi: 10.1038/s41386-018-0067-z.

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JVW-1034 (JVW1034)

Biological Activity

Physicochemical Properties

References

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