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JW-7-25-1

Chemical Structure : JW-7-25-1

CAS No.: 1222998-57-3

JW-7-25-1 (MELK inhibitor)

Catalog No.: PC-61764Not For Human Use, Lab Use Only.

JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM.
    JW-7-25-1 exhibits a broad kinase selectivity profile with an S(35) score of 0.54 at 10 uM.

    Physicochemical Properties

    M.Wt 516.524
    Formula C29H23F3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    9-(4-hydroxyphenyl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one

    References

    1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.

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