JW-7-25-1 | MELK inhibitor | Probechem Biochemicals

Chemical Structure : JW-7-25-1

JW-7-25-1 (MELK inhibitor)

Catalog No.: PC-61764Not For Human Use, Lab Use Only.

JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM.

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Biological Activity

JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM.
JW-7-25-1 exhibits a broad kinase selectivity profile with an S(35) score of 0.54 at 10 uM.

Physicochemical Properties

M.Wt	516.524
Formula	C29H23F3N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(4-hydroxyphenyl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one

References

1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.

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