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Chemical Structure : JW-7-25-1
Catalog No.: PC-61764Not For Human Use, Lab Use Only.
JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM.
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JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM.
JW-7-25-1 exhibits a broad kinase selectivity profile with an S(35) score of 0.54 at 10 uM.
| M.Wt | 516.524 | |
| Formula | C29H23F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.
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