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JW 642

Chemical Structure : JW 642

CAS No.: 1416133-89-5

JW 642 (JW-642, JW642)

Catalog No.: PC-42980Not For Human Use, Lab Use Only.

JW 642 (JW642) is a potent, selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6, 14 and 3.7 nM for mouse, rat and human MAGL, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JW 642 (JW642) is a potent, selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6, 14 and 3.7 nM for mouse, rat and human MAGL, respectively.
JW 642 display little to no activity against human FAAH (IC50>20 uM).

Physicochemical Properties

M.Wt 462.3855
Formula C21H20F6N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

References

1. Chang JW, et al. Chem Biol. 2012 May 25;19(5):579-88.

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