JW74 |CAS:863405-60-1 Probechem Biochemicals

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Chemical Structure : JW74

CAS No.: 863405-60-1

JW74 (Wnt inhibitor JW74;JW 74)

Catalog No.: PC-45698Not For Human Use, Lab Use Only.

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay.
JW74 reduces active β-catenin and downregulates Wnt target genes AXIN2, SP5, and NKD1.
JW74 inhibits tumor growth in mouse xenograft model.

Physicochemical Properties

M.Wt	456.5196
Formula	C24H20N6O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-

References

1. Waaler J, et al. Cancer Res. 2011 Jan 1;71(1):197-205.

2. Stratford EW, et al. Cancer Med. 2014 Feb;3(1):36-46.

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JW74 (Wnt inhibitor JW74;JW 74)

Biological Activity

Physicochemical Properties

References

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