Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Wnt/Notch/Hedgehog-Wnt-JW74
JW74

Chemical Structure : JW74

CAS No.: 863405-60-1

Add to Favorites

JW74 (Wnt inhibitor JW74;JW 74)

Catalog No.: PC-45698Not For Human Use, Lab Use Only.

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay.

Packing Price Stock Quantity
10 mg $98 In stock
25 mg $158 In stock
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay.
JW74 reduces active β-catenin and downregulates Wnt target genes AXIN2, SP5, and NKD1.
JW74 inhibits tumor growth in mouse xenograft model.

Physicochemical Properties

M.Wt 456.5196
Formula C24H20N6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-

References

1. Waaler J, et al. Cancer Res. 2011 Jan 1;71(1):197-205.

2. Stratford EW, et al. Cancer Med. 2014 Feb;3(1):36-46.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: