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JWD-065

Chemical Structure : JWD-065

CAS No.: 2250287-34-2

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JWD-065 (JWD 065)

Catalog No.: PC-73292Not For Human Use, Lab Use Only.

JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM.

Physicochemical Properties

M.Wt 462.572
Formula C24H26N6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

1. Sebum Lee, et al. Neuron. 2016, 91(1), 41-55.

2. Miduturu CV et al. Chem Biol. 2011;18:868–879.

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