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JWD-065

Chemical Structure : JWD-065

CAS No.: 2250287-34-2

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JWD-065 (JWD 065)

Catalog No.: PC-73292Not For Human Use, Lab Use Only.

JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM.

    Physicochemical Properties

    M.Wt 462.572
    Formula C24H26N6O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Propenamide, N-[3-[[4-amino-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-thiazolyl]carbonyl]phenyl]-

    References

    1. Sebum Lee, et al. Neuron. 2016, 91(1), 41-55.

    2. Miduturu CV et al. Chem Biol. 2011;18:868–879.

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