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Chemical Structure : JWX-A0108
Catalog No.: PC-21452Not For Human Use, Lab Use Only.
JWX-A0108 is a novel selective type I α7 nAChR positive allosteric modulator (PAM) with EC50 of 4.35 uM, shows no potentiation effect on α3β4 nAChR, α4β2 nAChR, or 5-HT3AR.
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JWX-A0108 is a novel selective type I α7 nAChR positive allosteric modulator (PAM) with EC50 of 4.35 uM, shows no potentiation effect on α3β4 nAChR, α4β2 nAChR, or 5-HT3AR.
JWX-A0108 selectively enhances the α7 current functionally expressed in oocytes.
JWX-A0108 (10 uM) potentiates the endogenous α7 current of cultured rat hippocampal neurons.
JWX-A0108 (10 uM) enhances GABAergic synaptic transmission in hippocampal brain slices.
JWX-A0108 (1-10 mg/kg, i.p.) reverses MK-801-induced deficits in auditory gating in MK-801-induced deficit in PPI in mice.
| M.Wt | 400.86 | |
| Formula | C19H14ClFN4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sun LL, et al. Acta Pharmacol Sin. 2019 Jun;40(6):737-745.
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