Chemical Structure : JWX-A0108
CAS No.:
2055045-42-4
JWX-A0108
(JWX A0108)
Catalog No.: PC-21452Not For Human Use, Lab Use Only.
JWX-A0108 is a novel selective type I α7 nAChR positive allosteric modulator (PAM) with EC50 of 4.35 uM, shows no potentiation effect on α3β4 nAChR, α4β2 nAChR, or 5-HT3AR.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JWX-A0108 is a novel selective type I α7 nAChR positive allosteric modulator (PAM) with EC50 of 4.35 uM, shows no potentiation effect on α3β4 nAChR, α4β2 nAChR, or 5-HT3AR.
JWX-A0108 selectively enhances the α7 current functionally expressed in oocytes.
JWX-A0108 (10 uM) potentiates the endogenous α7 current of cultured rat hippocampal neurons.
JWX-A0108 (10 uM) enhances GABAergic synaptic transmission in hippocampal brain slices.
JWX-A0108 (1-10 mg/kg, i.p.) reverses MK-801-induced deficits in auditory gating in MK-801-induced deficit in PPI in mice.
Physicochemical Properties
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M.Wt
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400.86
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Formula
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C19H14ClFN4OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-(2-chloro-6-methylphenyl)-2-((3-fluoro-4-methylphenyl)amino)thiazolo[4,5-d]pyrimidin-7(6H)-one
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References
1. Sun LL, et al. Acta Pharmacol Sin. 2019 Jun;40(6):737-745.
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