JWZ-1-80

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Chemical Structure : JWZ-1-80

Catalog No.: PC-21276Not For Human Use, Lab Use Only.

JWZ-1-80 is a potent and selective PROTAC degrader of PI5P4Kγ with Kd of 510 nM, 1 uM induces 75% reduction of PI5P4Kγ in Molt4 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JWZ-1-80 is a potent and selective PROTAC degrader of PI5P4Kγ with Kd of 510 nM, 1 uM induces 75% reduction of PI5P4Kγ in Molt4 cells.
JWZ-1-80 exhibits VHL-dependent mechanism for compound-induced degradation of PI5P4Kγ.
JWZ-1-80 does not induce degradation of PI5P4Kα or PI5P4Kβ, shows high specificity across the entire proteome.

Physicochemical Properties

M.Wt	1019.24
Formula	C56H62N10O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-((6-(1H-indol-3-yl)pyrimidin-4-yl)amino)phenyl)-N4-(5-(2-((S)-1-((2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamido)ethyl)-5-(4-methylthiazol-5-yl)phenoxy)pentyl)terephthalamide

References

1. Wenzhi Ji, et al. Eur J Med Chem. 2023 Feb 5:247:115027.

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JWZ-1-80

Biological Activity

Physicochemical Properties

References

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