Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JWZ-5-13
Catalog No.: PC-22665Not For Human Use, Lab Use Only.
JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner.
JWZ-5-13 (5 uM) induces CDK7 degradation across ovarian adenocarcinoma cell line OVCAR3, B-cell lymphoma cell line SUDHL5, and T lymphoblast cell line Molt4, lung adenocarcinoma cell line A549.
JWZ-5-13 induces CDK7 degradation in a UPS-dependent manner.
JWZ-5-13 is a selective CDK7 degrader across CDKs and proteome.
JWZ-5-13 displayed bioavailability in a pharmacokinetic study.
| M.Wt | 983.25 | |
| Formula | C54H66N10O6S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Wenzhi Ji, et al. Eur J Med Chem. 2024 Jun 27:276:116613.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
