Chemical Structure : JWZ-5-13
CAS No.:
JWZ-5-13
(CDK7 PROTAC)
Catalog No.: PC-22665Not For Human Use, Lab Use Only.
JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner.
JWZ-5-13 (5 uM) induces CDK7 degradation across ovarian adenocarcinoma cell line OVCAR3, B-cell lymphoma cell line SUDHL5, and T lymphoblast cell line Molt4, lung adenocarcinoma cell line A549.
JWZ-5-13 induces CDK7 degradation in a UPS-dependent manner.
JWZ-5-13 is a selective CDK7 degrader across CDKs and proteome.
JWZ-5-13 displayed bioavailability in a pharmacokinetic study.
Physicochemical Properties
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M.Wt
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983.25
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Formula
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C54H66N10O6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((S)-2-(dimethylamino)-1-phenylethyl)-3-(4-(6-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohex-1-yn-1-yl)benzamido)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
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References
1. Wenzhi Ji, et al. Eur J Med Chem. 2024 Jun 27:276:116613.
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