Chemical Structure : JWZ-8-103
CAS No.:
3109977-45-6
JWZ-8-103
Catalog No.: PC-26896Not For Human Use, Lab Use Only.
JWZ-8-103 is a potent TRIM21-targeting molecular glue triggering nuclear pore complex (NPC) degradation, is 10-fold more potent than PRLX-93936 against parental PANC-1 (IC50=9.5 nM) and H661 cells overexpressing high levels of ectopic TRIM21 (IC50 <10 nM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JWZ-8-103 is a potent TRIM21-targeting molecular glue triggering nuclear pore complex (NPC) degradation, is 10-fold more potent than PRLX-93936 against parental PANC-1 (IC50=9.5 nM) and H661 cells overexpressing high levels of ectopic TRIM21 (IC50 <10 nM).
JWZ-8-103 promotes a robust and rapid interaction between TRIM21 and NUP98 (apparent EC50=∼20 μM for TRIM21 PRYSPRY and NUP98 APD).
PRLX-93936 reduces levels of other short-lived prosurvival proteins, including MDM2 and c-MYC, with cell line-specific depletion patterns observed across multiple cell lines (Hs766T, KP3, MIA-PaCa2, and TRIM21 OE H661 cells), further supporting the broader consequences of NPC degradation.
JWZ-8-103 (15 or 50 mg/kg, i.p. injection) is sufficient to deplete several NUPs, effective against PANC-1 cell line–derived tumor murine xenografts.
Physicochemical Properties
|
M.Wt
|
416.88
|
|
Formula
|
C21H22ClFN4O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-(4-chloro-2-ethoxyphenyl)-6-fluoro-2-(piperazin-1-ylmethyl)quinazolin-4(3H)-one
|
References
1. Yuan L, et al. Cancer Discov. 2025 Dec 2;15(12):2505-2529.
Contact Us
sales@probechem.com
