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JX3212

Chemical Structure : JX3212

CAS No.:

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JX3212 (JX-3212)

Catalog No.: PC-26200Not For Human Use, Lab Use Only.

JX3212 is a potent, specific and brain penetrant inhibitor of inwardly rectifying potassium channel 4.1 (Kir4.1, KCNJ10) with IC50 of 0.28 uM (−120 mV) and 0.19 uM (+50 mV).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JX3212 is a potent, specific and brain penetrant inhibitor of inwardly rectifying potassium channel 4.1 (Kir4.1, KCNJ10) with IC50 of 0.28 uM (−120 mV) and 0.19 uM (+50 mV).
JX3212 shows minimal inhibition against Kir channel subtypes (Kir1.1/2.1/2.2/4.2).
JX3212 shows effective antidepressant activity in the novelty‐suppressed feeding test (NSFT) and chronic social defeat stress (CSDS) model.
JX3212 demonstrates superior safety margins compared to both (S)‐ketamine and the conventional antidepressant imipramine in murine behavioral assays.

Physicochemical Properties

M.Wt 403.49
Formula C23H25N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N4-(dibenzo[b,d]furan-2-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine

References

1. Sisi Wang, et al. Adv Sci (Weinh). 2026 Feb;13(9):e09506.

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