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JYQ-194

Chemical Structure : JYQ-194

CAS No.:

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JYQ-194 (JYQ194)

Catalog No.: PC-22303Not For Human Use, Lab Use Only.

JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells.
JYQ-194 induces PARK7 degradation in multiple tumor cell lines, via ubiquitin/proteasome system-dependent action.

Physicochemical Properties

M.Wt 903.92
Formula C39H38FN11O10S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R)-1-cyano-N-(5-(5-((4-((2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)sulfonyl)-2-fluorobenzoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrrolidine-3-carboxamide

References

1. Jia Y, et al. J Med Chem. 2024 May 7. doi: 10.1021/acs.jmedchem.3c02410.

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