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Chemical Structure : JYQ-194
Catalog No.: PC-22303Not For Human Use, Lab Use Only.
JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells.
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JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells.
JYQ-194 induces PARK7 degradation in multiple tumor cell lines, via ubiquitin/proteasome system-dependent action.
| M.Wt | 903.92 | |
| Formula | C39H38FN11O10S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jia Y, et al. J Med Chem. 2024 May 7. doi: 10.1021/acs.jmedchem.3c02410.
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