Chemical Structure : Jaceosidin
CAS No.:
18085-97-7
Jaceosidin
(4'-Demethyleupatilin;Jaseocidin)
Catalog No.: PC-36080Not For Human Use, Lab Use Only.
Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties; promotes angiogenesis via activation of VEGFR2/FAK/PI3K/AKT/NF-κB signaling pathways in endothelial cells; shows selective suppression of proliferation (IC50 = 82.1 μM in HSC-3 cells and 97.5 μM in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle, induces apoptotic cell death and inhibits the Akt pathway in oral cancer cells.
Physicochemical Properties
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M.Wt
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330.292
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Formula
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C17H14O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one
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References
1. Lee HG, et al. J Ethnopharmacol. 2005 Apr 26;98(3):339-43.
2. Han HY, et al. Evid Based Complement Alternat Med. 2018 May 13;2018:5765047.
3. Allison BJ, et al. Nat Prod Res. 2017 Mar;31(6):707-712.
4. Lee TH, et al. Exp Biol Med (Maywood). 2014 Oct;239(10):1325-34.
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