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K-7174

Chemical Structure : K-7174

CAS No.: 191089-59-5

K-7174 (K7174)

Catalog No.: PC-43168Not For Human Use, Lab Use Only.

K-7174 is a selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2).

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Biological Activity

K-7174 is a selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2).
K-7174 suppresses the expression of AR, including ARVs, in 22Rv1 cells, exertes potent anticancer activity against GATA2+/AR+ PC cell lines in vitro/
K-7174 induces transcriptional repression of class I histone deacetylases (HDAC1, -2, and -3) via caspase-8-dependent degradation of Sp1.
K-7174 significantly decreases HAMP expression, also upregulates CEBPB.

Physicochemical Properties

M.Wt 568.744
Formula C33H48N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-1,4-Diazepine, hexahydro-1,4-bis[(4E)-5-(3,4,5-trimethoxyphenyl)-4-penten-1-yl]-

References

1. He B, et al. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18261-6.

2. Kikuchi J, et al. J Biol Chem. 2013 Aug 30;288(35):25593-602.

3. Fujiwara T, et al. PLoS One. 2013 Sep 27;8(9):e75568.

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