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Chemical Structure : K-7174 dihydrochloride
CAS No.: 191089-60-8
Catalog No.: PC-43169Not For Human Use, Lab Use Only.
K-7174 dihydrochloride is a selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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K-7174 dihydrochloride is a selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2).
K-7174 dihydrochloride suppresses the expression of AR, including ARVs, in 22Rv1 cells, exertes potent anticancer activity against GATA2+/AR+ PC cell lines in vitro.
K-7174 dihydrochloride induces transcriptional repression of class I histone deacetylases (HDAC1, -2, and -3) via caspase-8-dependent degradation of Sp1.
K-7174 dihydrochloride significantly decreases HAMP expression, also upregulates CEBPB.
| M.Wt | 641.6659 | |
| Formula | C33H50Cl2N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: 15 mg/mL |
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| Chemical Name/SMILES |
1H-1,4-Diazepine, hexahydro-1,4-bis[(4E)-5-(3,4,5-trimethoxyphenyl)-4-penten-1-yl]-, hydrochloride (1:2) |
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1. He B, et al. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18261-6.
2. Kikuchi J, et al. J Biol Chem. 2013 Aug 30;288(35):25593-602.
3. Fujiwara T, et al. PLoS One. 2013 Sep 27;8(9):e75568.
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