Catalog No.: PC-23199Not For Human Use, Lab Use Only.
K-756 is a small molecule inhibitor of the Wnt/β-catenin pathway with IC50 of 110 nM in Wnt/β-catenin reporter assay, and selective tankyrase (TNKS) inhibitor with IC50 of 31 and 36 nM for TNKS1 and TNKS2, stabilizes Axin1/2 by inhibiting TNKS1/2.
K-756 is a small molecule inhibitor of the Wnt/β-catenin pathway with IC50 of 110 nM in Wnt/β-catenin reporter assay, and selective tankyrase (TNKS) inhibitor with IC50 of 31 and 36 nM for TNKS1 and TNKS2, stabilizes Axin1/2 by inhibiting TNKS1/2. K-756 binds to the induced pocket of TNKS and inhibits its enzyme activity. K-756 inhibited the cell growth of APC-mutant colorectal cancer COLO 320DM and SW403 cells by inhibiting the Wnt/β-catenin pathway. K-756 inhibited the Wnt/β-catenin pathway in colon cancer xenografts in mice. When K-756 was combined with an EGFR inhibitor (gefitinib), it showed a strong synergistic effect.
