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Chemical Structure : K-975
CAS No.: 2563855-03-6
Catalog No.: PC-72171Not For Human Use, Lab Use Only.
K-975 (K975, YAP1-TEAD inhibitor K975) is a potent, specific inhibitor of YAP1/TAZ-TEAD signaling, inhibits YAP1/TAZ-TEAD protein-protein interaction, a pan-TEAD inhibitor binds to Cys359 of TEAD1-YBD.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | Get quote |
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K-975 (K975, YAP1-TEAD inhibitor K975) is a potent, specific inhibitor of YAP1/TAZ-TEAD signaling, inhibits YAP1/TAZ-TEAD protein-protein interaction, a pan-TEAD inhibitor binds to Cys359 of TEAD1-YBD.
K-975 showed an inhibitory activity towards TEAD1-YAP1 PPI and TEAD4-YAP1 PPI in cells using a Halo-tag pull-down assay. Furthermore, K-975 inhibited the palmitoylation of TEAD1-YBD.
K-975 inhibits yes-associated protein 1 (YAP1)-transcriptional enhanced associate domain (TEAD) signaling by the same mechanism as YAP1 siRNA and TEADs siRNA.
K-975 decreased the expressions of CTGF, IGFBP3, and NPPB mRNAs, and increased the expression of FBXO32 mRNA with 24-h treatment in NCI-H226 cells.
K-975 exerts a stronger inhibitory activity towards neurofibromin 2 (NF2)-non-expressing mesothelioma cell lines.
K-975 exerts an anti-tumor effect and significant survival benefit in human mesothelioma xenograft mice.
K-975 exhibits a synergistic effect with a CDK4/6 inhibitor palbociclib in s.c. transplant mouse models of human mesothelioma.
| M.Wt | 287.743 | |
| Formula | C16H14ClNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-(4-chlorophenoxy)-4-methylphenyl)acrylamide |
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1. Kaneda A, et al. Am J Cancer Res. 2020 Dec 1;10(12):4399-4415.
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