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K1836

Chemical Structure : K1836

CAS No.:

K1836 (STAT3 inhibitor K1836)

Catalog No.: PC-20120Not For Human Use, Lab Use Only.

K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling, blocks STAT3 phosphorylation.

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    Biological Activity

    K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling, blocks STAT3 phosphorylation.
    K1836 inhibits critical components of senescence-associated secretory phenotype (SASP), including IL-6, GROα and MCP-1 production, which could theoretically modify the tumour microenvironment and interactions of tumour cells with the immune system.
    K1836 is able to modify the SASP by blocking secretion of pro-tumourigenic cytokines, including IL-6. 

    Physicochemical Properties

    M.Wt 325.34
    Formula C16H11N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(1,1-dioxidobenzo[b]thiophen-6-yl)-1H-pyrrolo[2,3-b]pyridine-4-carboxamide

    References

    1. Romana Mikyskova, et al. Mol Med Rep. 2023 Apr;27(4):81.

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