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Chemical Structure : K2071
Catalog No.: PC-23165Not For Human Use, Lab Use Only.
K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines.
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K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines.
K2071 is cytotoxic for glioblastoma cell lines. Human glioblastoma cell lines U-87 MG.
K2071 inhibits the growth of glioblastoma tumor spheroids.
Cytotoxic effect of K2071 is STAT3 inhibition-independent.
K2071 induces accumulation of mitotic cells. antimitotic activity arresting cells in prophase by altering mitotic spindle formation.
K2071 harbors a cytotoxic effect on TMZ-induced senescent glioblastoma U-87 MG cells and suppresses MCP-1 secretion.
| M.Wt | 301.36 | |
| Formula | C16H15NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patrik Oleksak, et al. ACS Pharmacol Transl Sci. 2024 Aug 12;7(9):2755-2783.
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