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Chemical Structure : K252a
CAS No.: 99533-80-9
Catalog No.: PC-70171Not For Human Use, Lab Use Only.
K252a (SF2370) is a potent, non-selective tyrosine protein kinase inhibitor for Trk family, CaMK and other phosphorylase kinases.
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K252a (SF2370) is a potent, non-selective tyrosine protein kinase inhibitor for Trk family, CaMK and other phosphorylase kinases.
K252a also partially inhibits PDGFR and inactive on the EGF, FGF and IGF-1 receptors.
K252a inhibits Met autophosphorylation in cultured cells and in immunoprecipitates and prevents activation of its downstream effectors MAPK and Akt.
K252a is a staurosporine analog.
| M.Wt | 467.5 | |
| Formula | C27H21N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
methyl (5R,7R,8S)-7-hydroxy-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxylate |
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1. Morotti A, et al. Oncogene. 2002 Jul 25;21(32):4885-93.
2. Ruggeri BA, et al. Curr Med Chem. 1999 Sep;6(9):845-57.
3. Tapley P, et al. Oncogene. 1992 Feb;7(2):371-81.
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