Chemical Structure : K2P16-i7
CAS No.:
1396765-69-7
K2P16-i7
(VU0544194)
Catalog No.: PC-27004Not For Human Use, Lab Use Only.
K2P16-i7 (VU0544194) is a potent, selective, reversible inhibitor of two-pore domain K+ (K2P) channel TALK-1 with IC50 of 5.2 uM, promotes β-cell function.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
K2P16-i7 (VU0544194) is a potent, selective, reversible inhibitor of two-pore domain K+ (K2P) channel TALK-1 with IC50 of 5.2 uM, promotes β-cell function.
K2P16-i7 does not affect other K+ channels (ie, TALK-2, TASK-3, KATP, and hERG).
K2P16-i7 inhibits TALK-1 channels localized to the ER membrane in addition to inhibiting Tl+ flux through TALK-1 channels in the plasma membrane.
K2P16-i7 inhibits primary β-cell TALK-1 currents and increases glucose-stimulated Ca2+ entry.
K2P16-i7 enhances insulin secretion from C57Bl/6J islets, promotes second-phase GSIS (glucose-stimulated insulin secretion).
Physicochemical Properties
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M.Wt
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339.35
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Formula
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C18H17N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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ethyl 5-(3-methoxybenzamido)pyrazolo[1,5-a]pyridine-3-carboxylate
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References
1. Nakhe AY, et al. Mol Pharmacol. 2026 May 15;108(5-6):100130.
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