K6PC-5 is a synthetic ceramide derivative, selective and direct sphingosine kinase 1 (SphK1) activator.
K6PC-5 ameliorates intestinal homeostasis in an animal model of Huntington's disease.
K6PC-5 increases intracellular calcium levels and promote epidermal keratinocyte differentiation, stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase.
K6PC-5 inhibits OGD/reoxygenation-induced myocardial cell death probably through activating SphK1.
K6PC-5 markedly reduces the EBOV titer in infected cells and the de novo production of viral proteins in endothelial cells.
