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K786-4469

Chemical Structure : K786-4469

CAS No.: 705955-57-3

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K786-4469

Catalog No.: PC-20482Not For Human Use, Lab Use Only.

K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1), suppresses cancer metastasis in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1, TMEM16A) channel, suppresses cancer metastasis in vitro and in vivo.
    K786-4469 not only decreased ANO1 expression and increased expression levels of its downstream targets CYP27A1, ABCA1 and ABCG1 in a dose-dependent manner accordingly, but also reduced the intracellular cholesterol level in ESCC cells.
    K786-4469 binds to ARG557 in ANO1 to repress cholesterol level and exert it's antimetastatic bioactivity through regulation of CYP27A1-LXR-ABCA1/ABCG1 axis.

    Physicochemical Properties

    M.Wt 614.76
    Formula C34H38N4O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(benzo[d][1,3]dioxol-5-ylmethyl)-1-cyclohexyl-2-(1-tosylpiperidin-4-yl)-1H-benzo[d]imidazole-5-carboxamide

    References

    1. Deng CM, et al. Cancer Res. 2023 Mar 13:CAN-22-3490.

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