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Chemical Structure : K786-4469
Catalog No.: PC-20482Not For Human Use, Lab Use Only.
K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1), suppresses cancer metastasis in vitro and in vivo.
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K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1, TMEM16A) channel, suppresses cancer metastasis in vitro and in vivo.
K786-4469 not only decreased ANO1 expression and increased expression levels of its downstream targets CYP27A1, ABCA1 and ABCG1 in a dose-dependent manner accordingly, but also reduced the intracellular cholesterol level in ESCC cells.
K786-4469 binds to ARG557 in ANO1 to repress cholesterol level and exert it's antimetastatic bioactivity through regulation of CYP27A1-LXR-ABCA1/ABCG1 axis.
| M.Wt | 614.76 | |
| Formula | C34H38N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Deng CM, et al. Cancer Res. 2023 Mar 13:CAN-22-3490.
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