KA2507 (KA-2507, KA 2507) is a potent and selective inhibitor of HDAC6 with IC50 of 2.5 nM, >300-fold selectivity over other HDACs.
KA2507 demonstrated cellular potency (IC50=150 nM) in a cellular assay measuring induction of acetylated α-tubulin, a marker of HDAC6 inhibition.
KA2507 displays antiproliferative effects against a set of 93 human cancer cells with IC50 of 2-30 uM.
KA2507 inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model.
