KAB-18 |CAS:741678-60-4 Probechem Biochemicals

Chemical Structure : KAB-18

KAB-18 (KAB18;KAB 18)

Catalog No.: PC-60678Not For Human Use, Lab Use Only.

A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM..

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Biological Activity

A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM.

Physicochemical Properties

M.Wt	413.561
Formula	C28H31NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-(3-phenylpropyl)piperidin-3-yl)methyl [1,1'-biphenyl]-2-carboxylate

References

1. Henderson BJ, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):761-74.

2. Pavlovicz RE, et al. PLoS One. 2011;6(9):e24949.

3. Henderson BJ, et al. ACS Chem Neurosci. 2012 Sep 19;3(9):682-92.

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KAB-18 (KAB18;KAB 18)

Biological Activity

Physicochemical Properties

References

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