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KAB-18

Chemical Structure : KAB-18

CAS No.: 741678-60-4

KAB-18 (KAB18;KAB 18)

Catalog No.: PC-60678Not For Human Use, Lab Use Only.

A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM.

Physicochemical Properties

M.Wt 413.561
Formula C28H31NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1-(3-phenylpropyl)piperidin-3-yl)methyl [1,1'-biphenyl]-2-carboxylate

References

1. Henderson BJ, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):761-74.

2. Pavlovicz RE, et al. PLoS One. 2011;6(9):e24949.

3. Henderson BJ, et al. ACS Chem Neurosci. 2012 Sep 19;3(9):682-92.

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