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Chemical Structure : KAR5417
Catalog No.: PC-62807Not For Human Use, Lab Use Only.
Rodatristat (KAR5417) is a potent, selective TPH1 (tryptophan hydroxylase-1) inhibitor with IC50 of 33 nM.
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Rodatristat (KAR5417) is a potent, selective TPH1 (tryptophan hydroxylase-1) inhibitor with IC50 of 33 nM.
Rodatristat (KAR5417) also shows potent inhibition of TPH2 (IC50=7 nM), an enzyme responsible for 5-HT production in the CNS, KAR5417 is found to be essentially confined to peripheral tissues in rats.
Rodatristat (KAR5417) produces robust 5-HT reduction in mice intestinal mucosa.
| M.Wt | 561.99 | |
| Formula | C27H27ClF3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goldberg DR, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):413-419.
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