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Chemical Structure : KAR5585
CAS No.: 1673571-51-1
Catalog No.: PC-62808Not For Human Use, Lab Use Only.
KAR5585 (Rodatristat ethyl) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice.
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|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $588 | In stock | |
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| 100 mg | Get quote |
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KAR5585 (Rodatristat ethyl) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice.
KAR5585 generates high and sustained systemic exposure of the active parent KAR5417 in rats and dogs; orally bioavailable.
| M.Wt | 590.044 | |
| Formula | C29H31ClF3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
ethyl (S)-8-(2-amino-6-((R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate |
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1. Goldberg DR, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):413-419.
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