Chemical Structure : KARI 201 hydrochloride
CAS No.:
2376132-24-8
KARI 201 hydrochloride
(KARI-201)
Catalog No.: PC-26583Not For Human Use, Lab Use Only.
KARI 201 hydrochloride (KARI-201) is a dual-action small molecule that exhibit highly selective inhibition effects on Acid sphingomyelinase (ASM), and act as a ghrelin receptor agonist.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KARI 201 hydrochloride (KARI-201) is a dual-action small molecule that exhibit highly selective inhibition effects on Acid sphingomyelinase (ASM), and act as a ghrelin receptor agonist.
KARI 201 is a competitive inhibitor that binds to the active site of ASM.
Incorporation of KARI 201 into ASM was decreased with increasing concentrations of sphingomyelin, yielding KM values of 332.5, 433.9, and 572.6 μM at 1, 10, and 100 μM KARI 201, respectively.
Administration of KARI 201 reduces amyloid pathology and restores cognitive impairment in APP/PS1 mice.
KARI 201 ameliorates defective autophagy degradation by regulating lysosomal biogenesis in neurons.
KARI 201 is a ghrelin receptor agonist and improves hippocampal neurogenesis and synapse plasticity.
Physicochemical Properties
|
M.Wt
|
320.86
|
|
Formula
|
C14H29ClN4O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-Amino-2-(1-nonyl-1H-1,2,3-triazol-4-yl)propane-1,3-diol hydrochloride
|
References
1. Wang M, et al. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2115082119.
Contact Us
sales@probechem.com
