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KB-141

Chemical Structure : KB-141

CAS No.: 219691-94-8

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KB-141 (KB141)

Catalog No.: PC-35610Not For Human Use, Lab Use Only.

KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ (THR-β) agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ (THR-β) agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα.
    KB-141 selectively reduces plasma cholesterol levels, also increases whole body oxygen consumption (MVO2) in both mice and rats.

    Physicochemical Properties

    M.Wt 355.21
    Formula C17H16Cl2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[3,5-dichloro-4-(4-hydroxy-3-propan-2-ylphenoxy)phenyl]acetic acid

    References

    1. Grover GJ, et al. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72.

    2. Johansson L, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302.

    3. Grover GJ, et al. Cardiovasc Drug Rev. 2005 Summer;23(2):133-48. Review.

    4. Ye L, et al. J Med Chem. 2003 Apr 24;46(9):1580-8.

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