KBP-7018 |CAS:1613437-66-3 Probechem Biochemicals

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Chemical Structure : KBP-7018

KBP-7018 (KBP 7018, KBP7018)

Catalog No.: PC-60151Not For Human Use, Lab Use Only.

KBP-7018 is a potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KBP-7018 is a potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.
KBP-7018 also potently inhibits FLT3, VEGFR2, Fyn, PDGFRα and VEGFR2.
KBP-7018 shows promising outcomes for the treatments of idiopathic pulmonary fibrosis (IPF).

Physicochemical Properties

M.Wt	538.604
Formula	C31H30N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (Z)-3-(((1-(2-morpholinoacetyl)indolin-5-yl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

References

1. Huang Z, et al. ACS Med Chem Lett. 2017 Sep 30;8(11):1142-1147.

2. Huang Z, et al. Drug Des Devel Ther. 2015 Aug 5;9:4319-28.

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KBP-7018 (KBP 7018, KBP7018)

Biological Activity

Physicochemical Properties

References

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