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KBP-7018 hydrochloride

Chemical Structure : KBP-7018 hydrochloride

CAS No.: 1613437-67-4

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KBP-7018 hydrochloride (KBP7018 hydrochloride)

Catalog No.: PC-60152Not For Human Use, Lab Use Only.

KBP-7018 hydrochloride is a potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KBP-7018 hydrochloride is a potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.
    KBP-7018 also potently inhibits FLT3, VEGFR2, Fyn, PDGFRα and VEGFR2.
    KBP-7018 shows promising outcomes for the treatments of idiopathic pulmonary fibrosis (IPF).

    Physicochemical Properties

    M.Wt 575.06
    Formula C31H31ClN4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Methyl (Z)-3-(((1-(2-morpholinoacetyl)indolin-5-yl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate hydrochloride

    References

    1. Huang Z, et al. ACS Med Chem Lett. 2017 Sep 30;8(11):1142-1147.

    2. Huang Z, et al. Drug Des Devel Ther. 2015 Aug 5;9:4319-28.

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