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KB SRC 4

Chemical Structure : KB SRC 4

CAS No.: 1380088-03-8

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KB SRC 4 (c-Src-IN-4)

Catalog No.: PC-62865Not For Human Use, Lab Use Only.

KB SRC 4 (c-Src-IN-4) is a potent, highly selective c-Src kinase inhibitor with Ki of 44 nM, does not inhibit c-Abl up to 125 uM, and binds to c-Src-TM (Q275G, C277Q, F278Y) with similar potency to that of wild-type c-Src.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KB SRC 4 (c-Src-IN-4) is a potent, highly selective c-Src kinase inhibitor with Ki of 44 nM, does not inhibit c-Abl up to 125 uM, and binds to c-Src-TM (Q275G, C277Q, F278Y) with similar potency to that of wild-type c-Src.
    KB SRC 4 significantly more efficacious than multi-kinase inhibition in cell culture.

    Physicochemical Properties

    M.Wt 555.042
    Formula C32H23ClN8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(1-([1,1'-biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl)phenyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

    References

    1. Brandvold KR, et al. ACS Chem Biol. 2012 Aug 17;7(8):1393-8.

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