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KC01

Chemical Structure : KC01

CAS No.: 1646795-59-6

KC01 (ABHD16A inhibitor KC01)

Catalog No.: PC-62262Not For Human Use, Lab Use Only.

KC01 is a potent and selective inhibitor of ABHD16A with IC50 of 90 nM for hABHD16A, 520 nM for mABHD16A.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KC01 is a potent and selective inhibitor of ABHD16A with IC50 of 90 nM for hABHD16A, 520 nM for mABHD16A.
    KC01 shows significant reductions in all detected cellular lyso-PSs, no activity in other lipids, including PSs, PCs, PEs, lyso-PCs, lyso-PEs, or monoacylglycerols (MAGs).
    KC01 decreases both lyso-PSs and lipopolysaccharide-induced cytokine production in mouse macrophages.

    Physicochemical Properties

    M.Wt 365.558
    Formula C22H39NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide

    References

    1. Kamat SS, et al. Nat Chem Biol. 2015 Feb;11(2):164-71.

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