Catalog No.: PC-21042Not For Human Use, Lab Use Only.
KD5170 (KD-5170) is a potent mercaptoketone-based Class I and II-histone deacetylase (HDAC) inhibitor with IC50 of 45 nM in HeLa cell-based histone H3 hyperacetylation assay.
KD5170 (KD-5170) is a potent mercaptoketone-based Class I and II-histone deacetylase (HDAC) inhibitor with IC50 of 45 nM in HeLa cell-based histone H3 hyperacetylation assay. KD5170 displays cytotoxic activities of KD5170 against cell lines from the NCI-60 panel with micromolar to submicromolar potency. KD5170 (30 mg/kg oral dose) increases tumor H3 hyperacetylation in vivo. KD5170 (42 and 84 mg/kg) exhibits significant tumor growth inhibition in HCT-116 tumor bearing nude mice.
