KDS2010 (KDS-2010, Tisolagiline) is a potent, highly selective, reversible Monoamine oxidase-B (MAO-B) inhibitor with IC50 of 7.6 nM.
KDS2010 displays 12,500-fold selectivity over MAO-A.
KDS2010 shows a marked enantiomer selectivity (eightfold selectivity) over the (R)-isomer.
KDS2010 significantly ameliorates the impairments in spike probability, learning, and memory in APP/PS1 mice, but not by selegiline, also reverses spatial learning and memory impairments in the Morris water maze test.
