Chemical Structure : KFP-H008
CAS No.:
1876453-55-2
KFP-H008
Catalog No.: PC-27265Not For Human Use, Lab Use Only.
KFP-H008 is a potent potassium-competitive acid blocker (P-CAB), exhibits inhibitory activities against H+-K+-ATPase with IC50 of 29 nM (pH 6.5 condition), does not affect Na+-K+-ATPase activity
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KFP-H008 is a potent potassium-competitive acid blocker (P-CAB), exhibits inhibitory activities against H+-K+-ATPase with IC50 of 29 nM (pH 6.5 condition), does not affect Na+-K+-ATPase activity
KFP-H008 inhibits basal acid secretion, 2-deoxy-D-glucose- (2DG-) stimulated gastric acid secretion in rats.
KFP-H008 blocked histamine-stimulated acid secretion in rats and heidenhain pouch dogs and reversed acid output in isolated gastric perfusion under histamine stimulation.
KFP-H008 inhibits H+-K+-ATPase activity both at pH 6.5 and pH 7.5, and is unaffected by pH, inhibits H+-K+-ATPase activity in a K+-competitive manner with Ki of 4 nM.
Physicochemical Properties
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M.Wt
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366.44
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Formula
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C19H18N4O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(5-(1H-indol-5-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
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References
1. Cheng-Yuan Li, et al. Eur J Pharmacol. 2017 Sep 5:810:112-119.
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