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KGA-2727

Chemical Structure : KGA-2727

CAS No.: 666842-36-0

KGA-2727 (KGA2727)

Catalog No.: PC-63375Not For Human Use, Lab Use Only.

KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2.
KGA-2727 attenuates the elevation of plasma glucose after glucose loading in streptozotocin-induced diabetic rats, preserves glucose-stimulated insulin secretion and reduces urinary glucose excretion with improved morphological changes of pancreatic islets and renal distal tubules in ZDF rats.

Physicochemical Properties

M.Wt 536.626
Formula C26H40N4O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((3-(4-((5-isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)propanamide

References

1. Shibazaki T, et al. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96.

2. Dobbins RL, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1;308(11):G946-54.

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