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KGP-420

Chemical Structure : KGP-420

CAS No.: 2082762-29-4

KGP-420 (KGP420)

Catalog No.: PC-62812Not For Human Use, Lab Use Only.

KGP-420 is the water-soluble phosphate prodrug of KGP-94 in vivo studies, KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM.

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    Biological Activity

    KGP-420 is the water-soluble phosphate prodrug of KGP-94 in vivo studies, KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM.
    KGP-420 readily converts to KGP-94, and shows cytotoxicity against HUVECs with GI50 of 20.2 uM.

    Physicochemical Properties

    M.Wt 476.192
    Formula C14H13BrN3Na2O4PS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-3-((3-bromophenyl)(2-carbamothioylhydrazono)methyl)phenyl dihydrogen phosphate, disodium salt

    References

    1. Parker EN, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1304-1310.

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