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KGP-94

Chemical Structure : KGP-94

CAS No.: 1131456-28-4

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KGP-94 (KGP94)

Catalog No.: PC-62813Not For Human Use, Lab Use Only.

KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM).
    KGP-94 significantly decreases the activity of cathepsin L toward human type I collagen, and impeds both migration and invasion of MDA-MB-231 human breast cancer cells.
    KGP-94 shows tumor growth retardation in a C3H mouse mammary carcinoma model.

    Physicochemical Properties

    M.Wt 350.234
    Formula C14H12BrN3OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [(E)-[(3-bromophenyl)(3-hydroxyphenyl)methylidene]amino]thiourea

    References

    1. Chavarria GE, et al. Eur J Med Chem. 2012 Dec;58:568-72.

    2. Parker EN, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1304-1310.

    3. Sudhan DR, et al. Clin Exp Metastasis. 2013 Oct;30(7):891-902.

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