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Chemical Structure : KGP-94
Catalog No.: PC-62813Not For Human Use, Lab Use Only.
KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM).
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KGP-94 is a potent, selective cathepsin L inhibitor with IC50 of 189 nM, shows no significant inhibitory effect on cathepsin B (IC50>10 uM).
KGP-94 significantly decreases the activity of cathepsin L toward human type I collagen, and impeds both migration and invasion of MDA-MB-231 human breast cancer cells.
KGP-94 shows tumor growth retardation in a C3H mouse mammary carcinoma model.
| M.Wt | 350.234 | |
| Formula | C14H12BrN3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chavarria GE, et al. Eur J Med Chem. 2012 Dec;58:568-72.
2. Parker EN, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1304-1310.
3. Sudhan DR, et al. Clin Exp Metastasis. 2013 Oct;30(7):891-902.
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