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Chemical Structure : KGP591
Catalog No.: PC-21387Not For Human Use, Lab Use Only.
KGP591 is a small molecule inhibitor of tubulin polymerization with IC50 of 0.57 uM, exhibits cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines with GI50 of 320 and 102 nM, respectively.
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KGP591 is a small molecule inhibitor of tubulin polymerization with IC50 of 0.57 uM, exhibits cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines with GI50 of 320 and 102 nM, respectively.
KGP594 at 0.5 μM demonstrates 51% inhibition of colchicine binding.
KGP591 (200 nM) treatment results in G2/M cell cycle arrest of MDA-MB-231 cells.
KGP591 disrupts microtubule structure and cell morphology in MDA-MB-231 cells, and demonstrates significant inhibition of MDA-MB-231 cell migration in a wound healing (scratch) assay.
| M.Wt | 403.43 | |
| Formula | C24H21NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ren W, et al. Eur J Med Chem. 2023 Sep 6;263:115794.
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