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KGP591

Chemical Structure : KGP591

CAS No.:

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KGP591 (KGP 591, KGP-591)

Catalog No.: PC-21387Not For Human Use, Lab Use Only.

KGP591 is a small molecule inhibitor of tubulin polymerization with IC50 of 0.57 uM, exhibits cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines with GI50 of 320 and 102 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KGP591 is a small molecule inhibitor of tubulin polymerization with IC50 of 0.57 uM, exhibits cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines with GI50 of 320 and 102 nM, respectively.
KGP594 at 0.5 μM demonstrates 51% inhibition of colchicine binding.
KGP591 (200 nM) treatment results in G2/M cell cycle arrest of MDA-MB-231 cells.
KGP591 disrupts microtubule structure and cell morphology in MDA-MB-231 cells, and demonstrates significant inhibition of MDA-MB-231 cell migration in a wound healing (scratch) assay.

Physicochemical Properties

M.Wt 403.43
Formula C24H21NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(6-(3-hydroxyphenyl)-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)methanone

References

1. Ren W, et al. Eur J Med Chem. 2023 Sep 6;263:115794.

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