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KIN-281

Chemical Structure : KIN-281

CAS No.: 74151-26-1

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KIN-281 (KIN281)

Catalog No.: PC-61630Not For Human Use, Lab Use Only.

KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively.
    KIN281 also inhibits BLK, CAMK Iiγ/δ, CAMK Iα, Tie2, BTK with IC50 of 1-10 uM.
    KIN281 inhibit STAT3 activation, autophagy and cancer cell anchorage-independent growth in MDA-MB-231 and MDA-MB-468 breast cancer cells.

    Physicochemical Properties

    M.Wt 506.9
    Formula C25H30Cl3N5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N4-(5-(diethylamino)pentan-2-yl)-2-(2,4,6-trichlorostyryl)quinazoline-4,6-diamine

    References

    1. Zhou D, et al. Bioorg Med Chem. 2017 Jun 15;25(12):2995-3005.

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