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Chemical Structure : KIN001-266
CAS No.: 915363-56-3
Catalog No.: PC-45794Not For Human Use, Lab Use Only.
Tpl2-IN-34 is a potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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KIN001-266 (Tpl2-IN-34) is a potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM.
Tpl2-IN-34 dispalys 6875-fold selectivity over EGFR. P38, Src, CAMKII, MK2, PKA, and PKC (IC50>10 uM).
Tpl2-IN-34 inhibits LPS-induced TNF-α production in whole blood with IC50 of 0.3 uM.
Tpl2-IN-34 shows good efficacy in inhibiting TNF-alpha production in a LPS-stimulated rat inflammation model; orally active.
| M.Wt | 539.4347 | |
| Formula | C26H25Cl2FN8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]- |
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1. Wu J, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.
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