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KIN1408

Chemical Structure : KIN1408

CAS No.: 1903800-11-2

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KIN1408 (KIN-1408, KIN 1408)

Catalog No.: PC-45765Not For Human Use, Lab Use Only.

KIN1408 (KIN-1408) is a small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KIN1408 (KIN-1408) is a small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus).
KIN1408 induces relocalization of pTBK1 from centrosomes to mitochondria, and increases CASP3-mediated cell death.
KIN1408 is the RIG-I-like receptor (RLR) agonist.

Physicochemical Properties

M.Wt 479.4985
Formula C25H19F2N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 39 mg/mL
Chemical Name/SMILES

7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol

References

1. Green RR, et al. Genom Data. 2016 Feb 1;7:290-2.

2. Pattabhi S, et al. J Virol. 2015 Dec 16;90(5):2372-87.

3. Onorati M, et al. Cell Rep. 2016 Sep 6;16(10):2576-92.

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