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Chemical Structure : KKL-40
Catalog No.: PC-61266Not For Human Use, Lab Use Only.
A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
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KKL-40 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
KKL-40 exhibited exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.44 ug/mL, respectively.
KKL-40 arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.
| M.Wt | 351.261 | |
| Formula | C16H9F4N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.
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