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KKL-40

Chemical Structure : KKL-40

CAS No.: 865285-47-8

KKL-40 (KKL40)

Catalog No.: PC-61266Not For Human Use, Lab Use Only.

A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KKL-40 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture.
KKL-40 exhibited exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.44 ug/mL, respectively.
KKL-40 arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.

Physicochemical Properties

M.Wt 351.261
Formula C16H9F4N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)benzamide

References

1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.

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