KMG-732 | Tubulin polymerization / GAK inhibitor

Chemical Structure : KMG-732

KMG-732 (KMG732)

Catalog No.: PC-27067Not For Human Use, Lab Use Only.

KMG-732 is a dual-targeting inhibitor of tubulin polymerization and cyclin G-associated kinase (GAK), targets the colchicine-binding site, effectively disrupts microtubule assembly and triggers mitotic arrest followed by apoptosis, significantly attenuates cancer cell migration and invasion.

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Biological Activity

Physicochemical Properties

M.Wt	391.44
Formula	C23H17N7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-6-(1H-indazol-3-yl)-4-(1-methyl-3-phenyl-1H-pyrazol-4-yl)nicotinonitrile

References

1. Seulki Park, et al. J Med Chem. 2026 Jun 15. doi: 10.1021/acs.jmedchem.6c00337.

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KMG-732 (KMG732)

Biological Activity

Physicochemical Properties

References

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