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Chemical Structure : KNT-127
Catalog No.: PC-70350Not For Human Use, Lab Use Only.
KNT-127 is a potent, selective δ-opioid receptor (DOR) agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively.
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KNT-127 is a potent, selective δ-opioid receptor (DOR) agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively.
KNT-127 significantly decreases the duration of immobility and increased the duration of swimming without influencing spontaneous locomotor activity in mice (1mg/kg, s.c.).
| M.Wt | 372.468 | |
| Formula | C24H24N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nagase H, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6302-5.
2. Saitoh A, et al. Behav Brain Res. 2011 Oct 1;223(2):271-9.
3. Tanahashi S, et al. Neuropharmacology. 2012 Apr;62(5-6):2057-67.
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