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KNa1.1 inhibitor 31

Chemical Structure : KNa1.1 inhibitor 31

CAS No.: 2540502-26-7

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KNa1.1 inhibitor 31

Catalog No.: PC-73241Not For Human Use, Lab Use Only.

KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).
    KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF.

    Physicochemical Properties

    M.Wt 434.302
    Formula C16H12F6N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-methyl-3-(trifluoromethyl)-N-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)-1,2,4-oxadiazol-5-yl)ethyl)-1H-pyrazole-5-carboxamide

    References

    1. Andrew M Griffin, et al. ACS Med Chem Lett. 2021 Mar 9;12(4):593-602.

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