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Chemical Structure : KNa1.1 inhibitor 31
Catalog No.: PC-73241Not For Human Use, Lab Use Only.
KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).
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KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).
KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF.
| M.Wt | 434.302 | |
| Formula | C16H12F6N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Andrew M Griffin, et al. ACS Med Chem Lett. 2021 Mar 9;12(4):593-602.
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