Catalog No.: PC-43212Not For Human Use, Lab Use Only.
KPT-9274 (Padnarsertib) is a potent, specific, dual NAMPT and PAK4 inhibitor with IC50 of 120 nM (NAMPT), also is an orally bioavailable PAK4 allosteric modulator with IC50 of 30 nM in MS-751 cell MTT assay.
KPT-9274 (Padnarsertib) is a potent, specific, dual NAMPT and PAK4 inhibitor with IC50 of 120 nM (NAMPT), also is an orally bioavailable PAK4 allosteric modulator with IC50 of 30 nM in MS-751 cell MTT assay.
KPT-9274 (Padnarsertib) attenuates the PAK4/β-catenin pathway, results in NAD depletion, and attenuates viability, invasion, and migration in several RCC cell lines (IC50=600 nM for Caki-1 cells).
KPT-9274 (Padnarsertib) attenuates G2/M transit and induces apoptosis, shows specificity for attenuation of NAD biosynthesis targets preferentially in RCC cells.
KPT-9274 (Padnarsertib) decreases tumor growth in xenograft model of RCC.
