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Chemical Structure : KPT-9274
CAS No.: 1643913-93-2
Catalog No.: PC-43212Not For Human Use, Lab Use Only.
KPT-9274 (Padnarsertib) is a potent, specific, dual NAMPT and PAK4 inhibitor with IC50 of 120 nM (NAMPT), also is an orally bioavailable PAK4 allosteric modulator with IC50 of 30 nM in MS-751 cell MTT assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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KPT-9274 (Padnarsertib) is a potent, specific, dual NAMPT and PAK4 inhibitor with IC50 of 120 nM (NAMPT), also is an orally bioavailable PAK4 allosteric modulator with IC50 of 30 nM in MS-751 cell MTT assay.
KPT-9274 (Padnarsertib) attenuates the PAK4/β-catenin pathway, results in NAD depletion, and attenuates viability, invasion, and migration in several RCC cell lines (IC50=600 nM for Caki-1 cells).
KPT-9274 (Padnarsertib) attenuates G2/M transit and induces apoptosis, shows specificity for attenuation of NAD biosynthesis targets preferentially in RCC cells.
KPT-9274 (Padnarsertib) decreases tumor growth in xenograft model of RCC.
| M.Wt | 610.625 | |
| Formula | C35H29F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, 3-(6-amino-3-pyridinyl)-N-[[5-[4-[(4,4-difluoro-1-piperidinyl)carbonyl]phenyl]-7-(4-fluorophenyl)-2-benzofuranyl]methyl]-, (2E)- |
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1. Abu Aboud O, et al. Mol Cancer Ther. 2016 Sep;15(9):2119-29.
2. Aboukameel A, et al. Mol Cancer Ther. 2017 Jan;16(1):76-87.
3. Fulciniti M, et al. Blood. 2017 Apr 20;129(16):2233-2245.
4. Rane C, et al. Sci Rep. 2017 Feb 15;7:42555.
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