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KR-32570

Chemical Structure : KR-32570

CAS No.: 852146-75-9

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KR-32570 (KR32570)

Catalog No.: PC-35054Not For Human Use, Lab Use Only.

KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM.
    KR-32570 significantly and concentration dependently improves cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release at 1-10 uM.
    KR-32570 possesses potent cardioprotective effects in perfused rat hearts.

    Physicochemical Properties

    M.Wt 293.707
    Formula C13H12ClN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylidene)furan-2-carboxamide

    References

    1. Lee BH, et al. Eur J Pharmacol. 2005 Mar 28;511(2-3):175-82.

    2. Lee S, et al. J Med Chem. 2005 Apr 21;48(8):2882-91.

    3. Kim MJ, et al. Eur J Pharmacol. 2005 Nov 21;525(1-3):1-7.

    4. Lee KS, et al. Arch Pharm Res. 2006 May;29(5):375-83.

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