KR-33028 |CAS:861218-37-3 Probechem Biochemicals

Chemical Structure : KR-33028

KR-33028 (KR33028)

Catalog No.: PC-35053Not For Human Use, Lab Use Only.

KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM.

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Biological Activity

KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM.
KR-33028 significantly decreases hypoxia-induced necrotic cell death and apoptotic cell death in H9c2 cells at 1-10 uM.
KR-33028 significantly inhibits hypoxia-induced increases in cytosolic and mitochondrial Ca2+ level and cytochrome c release, and recovered hypoxia-induced Delta psi(m) reduction.
KR-33028 demonstrates potent cardioprotective effects with minimal toxicity in perfused rat hearts.

Physicochemical Properties

M.Wt	244.272
Formula	C11H8N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-cyano-N-(diaminomethylene)benzo[b]thiophene-2-carboxamide

References

1. Jung YS, et al. Eur J Pharmacol. 2006 Mar 27;535(1-3):220-7.

2. Kim J, et al. Eur J Pharmacol. 2007 Jul 12;567(1-2):131-8.

3. Kim H, et al. Arch Pharm Res. 2005 Nov;28(11):1287-92.

4. Lee BK, et al. Brain Res. 2009 Jan 12;1248:22-30.

KR-33028 (KR33028)

Biological Activity

Physicochemical Properties

References

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